It's a fairly easy process, to tune with a Hemholtz, just need to find the frequency range where the exhaust is producing the annoyance and install the proper Hemholtz in the correct location to cancel that range of frequency out.
They work much like noise cancelling headphones.
I have a custom Hemholtz all stainless 3" system on my 40 series Inline six 2F engine with a header, no drone with great full throttle note, nothing too drastic, sounds stock unless getting into it. I also have a Hemoltz all stainless 3" system on my Tundra V8 that is much the same, with no drone, both made by the same exhaust wizard who knows how tune an exhaust.
This exhaust wizard is so good, I called him up to make an exhaust for my 40, my design his tuning and slight layout modification, a couple of sound recordings, knowing the engine type and talking back in forth for about 2 hours was all he needed to make the perfect setup that he had never done before.
Neither system cost more (all were less in fact) than the not properly tuned systems from TRD (in some cases), AFE, Borla, Magna flow and the like and allot of those come in Aluminized steel rather than stainless for the same price point.
Also running a full custom 3" stainless system with a universal aftermarket muffler setup on the 80 that has no drone either, but that is likely luck as there is no resonator on that setup at all, and my exhaust wizard had no hand in this one.
I ran no mufflers and just CATs on my Dodge Dakota V8, sounded sweet on throttle but droned something terrible (worse than my Camaro with glass packs, things you do when you're young!
It's all about whether it's designed properly!